Summit Supercomputer or OLCF-4 is the second fastest computer in the world, which is available in the Oak Ridge National Lab in Tennessee. Scientists have come up with a new theory with the help of supercomputer calculations for a better understanding of severe symptoms of COVID19. Scientists have used the OLCF-4 to observe the data of more than 40000 genes out of 17000 genetic samples to understand why symptoms of COVID19 take a severe toll on the human body. The experts have analyzed the data produced by the supercomputer, which has led to a breakthrough theory called the bradykin hypothesis. This report has been published in the Science journal of eLife.
The bradykin hypothesis is a model for observing the fatal symptoms of COVID19. It has also offered more than 10 potential treatments, which have been approved by the US Food and Drug Administration (FDA). Experts have said that coronavirus restricts the body from breaking down the chemical called bradykin, which is essential for regulating blood pressure. Experts have found that the accumulation of bradykin creates a bradykin storm. It causes weakening of blood vessels, which includes fluid seepage. Due to such kind of seepage, the lungs are filled with fluid and triggers inflammation. Later, it causes the most bizarre symptoms linked to COVID19. Experts have said COVID19 can trap the body to produce redundant hyaluronic acid (HLA), which is used in soaps and lotions. Scientists say that when HLA seeps inside the lungs, it absorbs leaked fluids from the vessels and forms a Hydrogel. The hydrogel can make the breathing so difficult that the patient can suffocate despite being on a ventilator
The bradykin hypothesis contributes to the effects of coronavirus on the heart and neurological system as well. As per the reports, at least one out of five COVID19 patients deals with heart issues despite having no history of cardiac diseases. The bradykin hypothesis has explained other symptoms linked to COVID19, such as seizures, dizziness, delirium, and stroke as well. A higher amount of bradykin can lead to a breakdown of the blood-brain barrier. The blood-brain barrier makes sure that unnecessary particles are filtered out from the blood when it reaches the brain. The collapse of the blood-brain barrier can cause many neurological symptoms among patients with COVID19 infection. Scientists have suggested a number of medicines approved by the FDA, which can be given for COVID19 symptoms linked to the bradykin hypothesis. Drugs such as danazol, stanozolol, and ecallantide can minimize the formation of bradykin and possibly can stop a bradykin storm.